Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood

المؤلفون المشاركون

Silva, Hellen Barbosa Farias
de Almeida, Ana Paula Carli
Cardoso, Katarine Barbosa
Ignacio-Souza, Letícia Martins
Reis, Silvia Regina de Lima
Reis, Marise Auxiliadora de Barros
Latorraca, Márcia Queiroz
Milanski, Marciane
Arantes, Vanessa Cristina

المصدر

Mediators of Inflammation

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-31

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

We evaluated whether protein restriction in fetal life alters food intake and glucose homeostasis in adulthood by interfering with insulin signal transduction through proinflammatory mechanisms in the hypothalamus and peripheral tissues.

Rats were divided into the following: a control group (C); a recovered group (R); and a low protein (LP) group.

Relative food intake was greater and serum leptin was diminished in LP and R compared to C rats.

Proinflammatory genes and POMC mRNA were upregulated in the hypothalamus of R group.

Hypothalamic NPY mRNA expression was greater but AKT phosphorylation was diminished in the LP than in the C rats.

In muscle, AKT phosphorylation was higher in restricted than in control animals.

The HOMA-IR was decreased in R and C compared to the LP group.

In contrast, the K itt in R was similar to that in C and both were lower than LP rats.

Thus, nutritional recovery did not alter glucose homeostasis but produced middle hyperphagia, possibly due to increased anorexigenic neuropeptide expression that counteracted the hypothalamic inflammatory process.

In long term protein deprived rats, hyperphagia most likely resulted from increased orexigenic neuropeptide expression, and glucose homeostasis was maintained, at least in part, at the expense of increased muscle insulin sensitivity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Silva, Hellen Barbosa Farias& de Almeida, Ana Paula Carli& Cardoso, Katarine Barbosa& Ignacio-Souza, Letícia Martins& Reis, Silvia Regina de Lima& Reis, Marise Auxiliadora de Barros…[et al.]. 2014. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043768

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Silva, Hellen Barbosa Farias…[et al.]. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043768

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Silva, Hellen Barbosa Farias& de Almeida, Ana Paula Carli& Cardoso, Katarine Barbosa& Ignacio-Souza, Letícia Martins& Reis, Silvia Regina de Lima& Reis, Marise Auxiliadora de Barros…[et al.]. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043768

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1043768