Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood
Joint Authors
Silva, Hellen Barbosa Farias
de Almeida, Ana Paula Carli
Cardoso, Katarine Barbosa
Ignacio-Souza, Letícia Martins
Reis, Silvia Regina de Lima
Reis, Marise Auxiliadora de Barros
Latorraca, Márcia Queiroz
Milanski, Marciane
Arantes, Vanessa Cristina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We evaluated whether protein restriction in fetal life alters food intake and glucose homeostasis in adulthood by interfering with insulin signal transduction through proinflammatory mechanisms in the hypothalamus and peripheral tissues.
Rats were divided into the following: a control group (C); a recovered group (R); and a low protein (LP) group.
Relative food intake was greater and serum leptin was diminished in LP and R compared to C rats.
Proinflammatory genes and POMC mRNA were upregulated in the hypothalamus of R group.
Hypothalamic NPY mRNA expression was greater but AKT phosphorylation was diminished in the LP than in the C rats.
In muscle, AKT phosphorylation was higher in restricted than in control animals.
The HOMA-IR was decreased in R and C compared to the LP group.
In contrast, the K itt in R was similar to that in C and both were lower than LP rats.
Thus, nutritional recovery did not alter glucose homeostasis but produced middle hyperphagia, possibly due to increased anorexigenic neuropeptide expression that counteracted the hypothalamic inflammatory process.
In long term protein deprived rats, hyperphagia most likely resulted from increased orexigenic neuropeptide expression, and glucose homeostasis was maintained, at least in part, at the expense of increased muscle insulin sensitivity.
American Psychological Association (APA)
Silva, Hellen Barbosa Farias& de Almeida, Ana Paula Carli& Cardoso, Katarine Barbosa& Ignacio-Souza, Letícia Martins& Reis, Silvia Regina de Lima& Reis, Marise Auxiliadora de Barros…[et al.]. 2014. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043768
Modern Language Association (MLA)
Silva, Hellen Barbosa Farias…[et al.]. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043768
American Medical Association (AMA)
Silva, Hellen Barbosa Farias& de Almeida, Ana Paula Carli& Cardoso, Katarine Barbosa& Ignacio-Souza, Letícia Martins& Reis, Silvia Regina de Lima& Reis, Marise Auxiliadora de Barros…[et al.]. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043768