Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus
المؤلفون المشاركون
Ding, Jianbing
Pang, Nannan
Zhang, Fengbo
Ma, Xiumin
Zhang, Zhaoxia
Zhao, Hui
Xin, Yan
Wang, Song
Zhu, Yuejie
Wen, Hao
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Th9 cells have been reported to contribute to immune responses; however, the role of Th9 cells in Echinococcus granulosus infection is unknown.
This study is to determine whether Th9 cells and IL-9 are involved in human Echinococcus granulosus infection.
Compared with healthy controls (HC group), the mRNA levels of PU.1, IL-9, and GATA-3 were significantly increased in patients before therapy (CE group), as revealed by qRT-PCR.
Flow cytometry analysis showed that the percentages of Th9 and Th2 cells in CE group were significantly higher.
The levels of IL-9, IL-4, IL-10, and TGF-β in CE group were also significantly increased, as detected by CBA assay.
The percentages of Th9 and Th2 cells in CE group were positively correlated.
After treatments of surgery in combination with albendazole, the PU.1 and GATA-3 mRNA levels were significantly decreased in patients after therapy (PCE group) compared with CE group.
The numbers of Th9 and Th2 cells and levels of IL-9, IL-4, IL-10, and TGF-β were also significantly decreased in PCE group.
In conclusion, the ratios of Th9 cells and IL-9 levels were significantly decreased after treatment, suggesting that Th9/IL-9 may be involved in immune response induced by Echinococcus granulosus infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pang, Nannan& Zhang, Fengbo& Ma, Xiumin& Zhang, Zhaoxia& Zhao, Hui& Xin, Yan…[et al.]. 2014. Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043805
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pang, Nannan…[et al.]. Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043805
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pang, Nannan& Zhang, Fengbo& Ma, Xiumin& Zhang, Zhaoxia& Zhao, Hui& Xin, Yan…[et al.]. Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043805
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043805
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر