Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus
Joint Authors
Ding, Jianbing
Pang, Nannan
Zhang, Fengbo
Ma, Xiumin
Zhang, Zhaoxia
Zhao, Hui
Xin, Yan
Wang, Song
Zhu, Yuejie
Wen, Hao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Th9 cells have been reported to contribute to immune responses; however, the role of Th9 cells in Echinococcus granulosus infection is unknown.
This study is to determine whether Th9 cells and IL-9 are involved in human Echinococcus granulosus infection.
Compared with healthy controls (HC group), the mRNA levels of PU.1, IL-9, and GATA-3 were significantly increased in patients before therapy (CE group), as revealed by qRT-PCR.
Flow cytometry analysis showed that the percentages of Th9 and Th2 cells in CE group were significantly higher.
The levels of IL-9, IL-4, IL-10, and TGF-β in CE group were also significantly increased, as detected by CBA assay.
The percentages of Th9 and Th2 cells in CE group were positively correlated.
After treatments of surgery in combination with albendazole, the PU.1 and GATA-3 mRNA levels were significantly decreased in patients after therapy (PCE group) compared with CE group.
The numbers of Th9 and Th2 cells and levels of IL-9, IL-4, IL-10, and TGF-β were also significantly decreased in PCE group.
In conclusion, the ratios of Th9 cells and IL-9 levels were significantly decreased after treatment, suggesting that Th9/IL-9 may be involved in immune response induced by Echinococcus granulosus infection.
American Psychological Association (APA)
Pang, Nannan& Zhang, Fengbo& Ma, Xiumin& Zhang, Zhaoxia& Zhao, Hui& Xin, Yan…[et al.]. 2014. Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043805
Modern Language Association (MLA)
Pang, Nannan…[et al.]. Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043805
American Medical Association (AMA)
Pang, Nannan& Zhang, Fengbo& Ma, Xiumin& Zhang, Zhaoxia& Zhao, Hui& Xin, Yan…[et al.]. Th9IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043805