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Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes
المؤلفون المشاركون
Marzi, Ingo
Lehnert, Mark
Maraslioglu, Miriam
Oppermann, Elsie
Blattner, Carolin
Weber, Roxane
Jobin, Christian
Schleucher, Elke
Henrich, Dirk
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Chronic ethanol abuse is known to increase susceptibility to infections after injury, in part, by modification of macrophage function.
Several intracellular signalling mechanisms are involved in the initiation of inflammatory responses, including the nuclear factor-κB (NF-κB) pathway.
In this study, we investigated the systemic and hepatic effect of chronic ethanol feeding on in vivo activation of NF-κB in NF-κBEGFP reporter gene mice.
Specifically, the study focused on Kupffer cell proinflammatory cytokines IL-6 and TNF-α and activation of NF-κB after chronic ethanol feeding followed by in vitro stimulation with lipopolysaccharide (LPS).
We found that chronic ethanol upregulated NF-κB activation and increased hepatic and systemic proinflammatory cytokine levels.
Similarly, LPS-stimulated IL-1β release from whole blood was significantly enhanced in ethanol-fed mice.
However, LPS significantly increased IL-6 and TNF-α levels.
These results demonstrate that chronic ethanol feeding can improve the responsiveness of macrophage LPS-stimulated IL-6 and TNF-α production and indicate that this effect may result from ethanol-induced alterations in intracellular signalling through NF-κB.
Furthermore, LPS and TNF-α stimulated the gene expression of different inflammatory mediators, in part, in a NF-κB-dependent manner.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maraslioglu, Miriam& Oppermann, Elsie& Blattner, Carolin& Weber, Roxane& Henrich, Dirk& Jobin, Christian…[et al.]. 2014. Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maraslioglu, Miriam…[et al.]. Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes. Mediators of Inflammation No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1043823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maraslioglu, Miriam& Oppermann, Elsie& Blattner, Carolin& Weber, Roxane& Henrich, Dirk& Jobin, Christian…[et al.]. Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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