Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis
المؤلفون المشاركون
Hou, Yu-Chen
Wu, Jin-Ming
Wang, Ming-Yang
Wu, Ming-Hsun
Chen, Kuen-Yuan
Lin, Ming-Tsan
Yeh, Sung-Ling
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-07
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Migration of T cells into the colon plays a major role in the pathogenesis in inflammatory bowel disease.
This study investigated the effects of glutamine (Gln) supplementation on chemokine receptors and adhesion molecules expressed by T cells in mice with dextran sulfate sodium- (DSS-) induced colitis.
Methods.
C57BL/6 mice were fed either a standard diet or a Gln diet replacing 25% of the total nitrogen.
After being fed the diets for 5 days, half of the mice from both groups were given 1.5% DSS in drinking water to induce colitis.
Mice were killed after 5 days of DSS exposure.
Results.
DSS colitis resulted in higher expression levels of P-selectin glycoprotein ligand- (PSGL-) 1, leukocyte function-associated antigen- (LFA-) 1, and C-C chemokine receptor type 9 (CCR9) by T helper (Th) and cytotoxic T (Tc) cells, and mRNA levels of endothelial adhesion molecules in colons were upregulated.
Gln supplementation decreased expressions of PSGL-1, LFA-1, and CCR9 by Th cells.
Colonic gene expressions of endothelial adhesion molecules were also lower in Gln-colitis mice.
Histological finding showed that colon infiltrating Th cells were less in the DSS group with Gln administration.
Conclusions.
Gln supplementation may ameliorate the inflammation of colitis possibly via suppression of T cell migration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hou, Yu-Chen& Wu, Jin-Ming& Wang, Ming-Yang& Wu, Ming-Hsun& Chen, Kuen-Yuan& Yeh, Sung-Ling…[et al.]. 2014. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hou, Yu-Chen…[et al.]. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hou, Yu-Chen& Wu, Jin-Ming& Wang, Ming-Yang& Wu, Ming-Hsun& Chen, Kuen-Yuan& Yeh, Sung-Ling…[et al.]. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر