Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis
Joint Authors
Hou, Yu-Chen
Wu, Jin-Ming
Wang, Ming-Yang
Wu, Ming-Hsun
Chen, Kuen-Yuan
Lin, Ming-Tsan
Yeh, Sung-Ling
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Migration of T cells into the colon plays a major role in the pathogenesis in inflammatory bowel disease.
This study investigated the effects of glutamine (Gln) supplementation on chemokine receptors and adhesion molecules expressed by T cells in mice with dextran sulfate sodium- (DSS-) induced colitis.
Methods.
C57BL/6 mice were fed either a standard diet or a Gln diet replacing 25% of the total nitrogen.
After being fed the diets for 5 days, half of the mice from both groups were given 1.5% DSS in drinking water to induce colitis.
Mice were killed after 5 days of DSS exposure.
Results.
DSS colitis resulted in higher expression levels of P-selectin glycoprotein ligand- (PSGL-) 1, leukocyte function-associated antigen- (LFA-) 1, and C-C chemokine receptor type 9 (CCR9) by T helper (Th) and cytotoxic T (Tc) cells, and mRNA levels of endothelial adhesion molecules in colons were upregulated.
Gln supplementation decreased expressions of PSGL-1, LFA-1, and CCR9 by Th cells.
Colonic gene expressions of endothelial adhesion molecules were also lower in Gln-colitis mice.
Histological finding showed that colon infiltrating Th cells were less in the DSS group with Gln administration.
Conclusions.
Gln supplementation may ameliorate the inflammation of colitis possibly via suppression of T cell migration.
American Psychological Association (APA)
Hou, Yu-Chen& Wu, Jin-Ming& Wang, Ming-Yang& Wu, Ming-Hsun& Chen, Kuen-Yuan& Yeh, Sung-Ling…[et al.]. 2014. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043842
Modern Language Association (MLA)
Hou, Yu-Chen…[et al.]. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043842
American Medical Association (AMA)
Hou, Yu-Chen& Wu, Jin-Ming& Wang, Ming-Yang& Wu, Ming-Hsun& Chen, Kuen-Yuan& Yeh, Sung-Ling…[et al.]. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043842