Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation
المؤلفون المشاركون
De Falco, Elena
Carnevale, Roberto
Chimenti, Isotta
Peruzzi, Mariangela
Marullo, Antonino G. M.
Frati, Giacomo
Biondi-Zoccai, Giuseppe
Pastori, Daniele
Greco, Ernesto
Nocella, Cristina
Pignatelli, Pasquale
Calvieri, Camilla
Violi, Francesco
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Adiponectin (APN) possesses anti-inflammatory and antiatherogenic effects.
Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L).
The interplay between APN and platelet activation in AF is still undefined.
Materials and Methods.
Circulating levels of APN and sCD40L were measured in 257 anticoagulated nonvalvular AF patients.
Exclusion criteria were as follows: prosthetic heart valves, cardiac revascularization in the previous year, severe cognitive impairment, chronic infectious or autoimmune diseases, and active cancer.
Results.
Mean age was 72.9 (±8.7) years and 41.6% were female.
Serum APN and plasmatic sCD40L were inversely correlated ( R −0.626, P < 0.001 ).
A progressive increase of sCD40L across tertiles of CHA2DS2-VASc score was observed (rS 0.473, P < 0.001 ), whilst APN was inversely correlated (rS −0.463, P < 0.001 ).
A multivariable linear regression analysis showed that CHA2DS2-VASc score ( B −0.227, P < 0.001 ) and sCD40L ( B −0.524, P < 0.001 ) correlated to APN.
Conclusions.
AF patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation in vivo in this clinical setting.
Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carnevale, Roberto& Pastori, Daniele& Peruzzi, Mariangela& De Falco, Elena& Chimenti, Isotta& Biondi-Zoccai, Giuseppe…[et al.]. 2014. Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043879
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carnevale, Roberto…[et al.]. Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation. Mediators of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043879
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carnevale, Roberto& Pastori, Daniele& Peruzzi, Mariangela& De Falco, Elena& Chimenti, Isotta& Biondi-Zoccai, Giuseppe…[et al.]. Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043879
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043879
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر