Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation
Joint Authors
De Falco, Elena
Carnevale, Roberto
Chimenti, Isotta
Peruzzi, Mariangela
Marullo, Antonino G. M.
Frati, Giacomo
Biondi-Zoccai, Giuseppe
Pastori, Daniele
Greco, Ernesto
Nocella, Cristina
Pignatelli, Pasquale
Calvieri, Camilla
Violi, Francesco
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Adiponectin (APN) possesses anti-inflammatory and antiatherogenic effects.
Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L).
The interplay between APN and platelet activation in AF is still undefined.
Materials and Methods.
Circulating levels of APN and sCD40L were measured in 257 anticoagulated nonvalvular AF patients.
Exclusion criteria were as follows: prosthetic heart valves, cardiac revascularization in the previous year, severe cognitive impairment, chronic infectious or autoimmune diseases, and active cancer.
Results.
Mean age was 72.9 (±8.7) years and 41.6% were female.
Serum APN and plasmatic sCD40L were inversely correlated ( R −0.626, P < 0.001 ).
A progressive increase of sCD40L across tertiles of CHA2DS2-VASc score was observed (rS 0.473, P < 0.001 ), whilst APN was inversely correlated (rS −0.463, P < 0.001 ).
A multivariable linear regression analysis showed that CHA2DS2-VASc score ( B −0.227, P < 0.001 ) and sCD40L ( B −0.524, P < 0.001 ) correlated to APN.
Conclusions.
AF patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation in vivo in this clinical setting.
Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients.
American Psychological Association (APA)
Carnevale, Roberto& Pastori, Daniele& Peruzzi, Mariangela& De Falco, Elena& Chimenti, Isotta& Biondi-Zoccai, Giuseppe…[et al.]. 2014. Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043879
Modern Language Association (MLA)
Carnevale, Roberto…[et al.]. Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation. Mediators of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043879
American Medical Association (AMA)
Carnevale, Roberto& Pastori, Daniele& Peruzzi, Mariangela& De Falco, Elena& Chimenti, Isotta& Biondi-Zoccai, Giuseppe…[et al.]. Total Adiponectin Is Inversely Associated with Platelet Activation and CHA 2DS 2-VASc Score in Anticoagulated Patients with Atrial Fibrillation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043879