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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
المؤلفون المشاركون
Bouvier, David S.
Jones, Emma Victoria
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation.
Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases.
In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development.
These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry.
Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jones, Emma Victoria& Bouvier, David S.. 2014. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease. Neural Plasticity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046680
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jones, Emma Victoria& Bouvier, David S.. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease. Neural Plasticity No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046680
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jones, Emma Victoria& Bouvier, David S.. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046680
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046680
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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