![](/images/graphics-bg.png)
Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Joint Authors
Bouvier, David S.
Jones, Emma Victoria
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation.
Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases.
In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development.
These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry.
Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.
American Psychological Association (APA)
Jones, Emma Victoria& Bouvier, David S.. 2014. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease. Neural Plasticity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046680
Modern Language Association (MLA)
Jones, Emma Victoria& Bouvier, David S.. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease. Neural Plasticity No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046680
American Medical Association (AMA)
Jones, Emma Victoria& Bouvier, David S.. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046680