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Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF
المؤلفون المشاركون
Chadi, Gerson
Batista, Chary Marquez
Bianqui, Leonardo Luis Torres
Zanon, Bruno Bonganha
Ivo, Mauricio Menezes Aben Athar
de Oliveira, Gabriela Pintar
Maximino, Jessica Ruivo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-03
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown.
Rats received a low thoracic SC photothrombotic ischemia and local injection of PEDF and were evaluated behaviorally six weeks later.
PEDF actions were detailed in SC ventral horn (motor) in the levels of the lumbar central pattern generator (CPG), far from the injury site.
Molecules related to neuroplasticity (MAP-2), those that are able to modulate such event, for instance, neurotrophic factors (NT-3, GDNF, BDNF, and FGF-2), chondroitin sulfate proteoglycans (CSPG), and those associated with angiogenesis and antiapoptosis (laminin and Bcl-2) and Eph (receptor)/ephrin system were evaluated at cellular or molecular levels.
PEDF injection improved motor behavioral performance and increased MAP-2 levels and dendritic processes in the region of lumbar CPG.
Treatment also elevated GDNF and decreased NT-3, laminin, and CSPG.
Injury elevated EphA4 and ephrin-B1 levels, and PEDF treatment increased ephrin A2 and ephrins B1, B2, and B3.
Eph receptors and ephrins were found in specific populations of neurons and astrocytes.
PEDF treatment to SC injury triggered neuroplasticity in lumbar CPG and regulation of neurotrophic factors, extracellular matrix molecules, and ephrins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Batista, Chary Marquez& Bianqui, Leonardo Luis Torres& Zanon, Bruno Bonganha& Ivo, Mauricio Menezes Aben Athar& de Oliveira, Gabriela Pintar& Maximino, Jessica Ruivo…[et al.]. 2014. Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1046693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Batista, Chary Marquez…[et al.]. Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1046693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Batista, Chary Marquez& Bianqui, Leonardo Luis Torres& Zanon, Bruno Bonganha& Ivo, Mauricio Menezes Aben Athar& de Oliveira, Gabriela Pintar& Maximino, Jessica Ruivo…[et al.]. Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1046693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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