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Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF
Joint Authors
Chadi, Gerson
Batista, Chary Marquez
Bianqui, Leonardo Luis Torres
Zanon, Bruno Bonganha
Ivo, Mauricio Menezes Aben Athar
de Oliveira, Gabriela Pintar
Maximino, Jessica Ruivo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown.
Rats received a low thoracic SC photothrombotic ischemia and local injection of PEDF and were evaluated behaviorally six weeks later.
PEDF actions were detailed in SC ventral horn (motor) in the levels of the lumbar central pattern generator (CPG), far from the injury site.
Molecules related to neuroplasticity (MAP-2), those that are able to modulate such event, for instance, neurotrophic factors (NT-3, GDNF, BDNF, and FGF-2), chondroitin sulfate proteoglycans (CSPG), and those associated with angiogenesis and antiapoptosis (laminin and Bcl-2) and Eph (receptor)/ephrin system were evaluated at cellular or molecular levels.
PEDF injection improved motor behavioral performance and increased MAP-2 levels and dendritic processes in the region of lumbar CPG.
Treatment also elevated GDNF and decreased NT-3, laminin, and CSPG.
Injury elevated EphA4 and ephrin-B1 levels, and PEDF treatment increased ephrin A2 and ephrins B1, B2, and B3.
Eph receptors and ephrins were found in specific populations of neurons and astrocytes.
PEDF treatment to SC injury triggered neuroplasticity in lumbar CPG and regulation of neurotrophic factors, extracellular matrix molecules, and ephrins.
American Psychological Association (APA)
Batista, Chary Marquez& Bianqui, Leonardo Luis Torres& Zanon, Bruno Bonganha& Ivo, Mauricio Menezes Aben Athar& de Oliveira, Gabriela Pintar& Maximino, Jessica Ruivo…[et al.]. 2014. Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1046693
Modern Language Association (MLA)
Batista, Chary Marquez…[et al.]. Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1046693
American Medical Association (AMA)
Batista, Chary Marquez& Bianqui, Leonardo Luis Torres& Zanon, Bruno Bonganha& Ivo, Mauricio Menezes Aben Athar& de Oliveira, Gabriela Pintar& Maximino, Jessica Ruivo…[et al.]. Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1046693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046693