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Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo
المؤلفون المشاركون
Dringenberg, Hans C.
Branfield Day, Leora R.
Choi, Deanna H.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Several recent studies have provided evidence that chronic treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine can facilitate synaptic plasticity (e.g., ocular dominance shifts) in the adult central nervous system.
Here, we assessed whether fluoxetine enhances long-term potentiation (LTP) in the thalamocortical auditory system of mature rats, a developmentally regulated form of plasticity that shows a characteristic decline during postnatal life.
Adult rats were chronically treated with fluoxetine (administered in the drinking water, 0.2 mg/mL, four weeks of treatment).
Electrophysiological assessments were conducted using an anesthetized (urethane) in vivo preparation, with LTP of field potentials in the primary auditory cortex (A1) induced by theta-burst stimulation of the medial geniculate nucleus.
We find that, compared to water-treated control animals, fluoxetine-treated rats did not express higher levels of LTP and, in fact, exhibited reduced levels of potentiation at presumed intracortical A1 synapses.
Bioactivity of fluoxetine was confirmed by a reduction of weight gain and fluid intake during the four-week treatment period.
We conclude that chronic fluoxetine treatment fails to enhance LTP in the mature rodent thalamocortical auditory system, results that bring into question the notion that SSRIs act as general facilitators of synaptic plasticity in the mammalian forebrain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dringenberg, Hans C.& Branfield Day, Leora R.& Choi, Deanna H.. 2014. Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo. Neural Plasticity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dringenberg, Hans C.…[et al.]. Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo. Neural Plasticity No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dringenberg, Hans C.& Branfield Day, Leora R.& Choi, Deanna H.. Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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