Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo
Joint Authors
Dringenberg, Hans C.
Branfield Day, Leora R.
Choi, Deanna H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several recent studies have provided evidence that chronic treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine can facilitate synaptic plasticity (e.g., ocular dominance shifts) in the adult central nervous system.
Here, we assessed whether fluoxetine enhances long-term potentiation (LTP) in the thalamocortical auditory system of mature rats, a developmentally regulated form of plasticity that shows a characteristic decline during postnatal life.
Adult rats were chronically treated with fluoxetine (administered in the drinking water, 0.2 mg/mL, four weeks of treatment).
Electrophysiological assessments were conducted using an anesthetized (urethane) in vivo preparation, with LTP of field potentials in the primary auditory cortex (A1) induced by theta-burst stimulation of the medial geniculate nucleus.
We find that, compared to water-treated control animals, fluoxetine-treated rats did not express higher levels of LTP and, in fact, exhibited reduced levels of potentiation at presumed intracortical A1 synapses.
Bioactivity of fluoxetine was confirmed by a reduction of weight gain and fluid intake during the four-week treatment period.
We conclude that chronic fluoxetine treatment fails to enhance LTP in the mature rodent thalamocortical auditory system, results that bring into question the notion that SSRIs act as general facilitators of synaptic plasticity in the mammalian forebrain.
American Psychological Association (APA)
Dringenberg, Hans C.& Branfield Day, Leora R.& Choi, Deanna H.. 2014. Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo. Neural Plasticity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046714
Modern Language Association (MLA)
Dringenberg, Hans C.…[et al.]. Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo. Neural Plasticity No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046714
American Medical Association (AMA)
Dringenberg, Hans C.& Branfield Day, Leora R.& Choi, Deanna H.. Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046714