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Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons
المؤلفون المشاركون
Park, A-Reum
Lee, Hae In
Semjid, Dejidnorov
Kim, Do Kyung
Chun, Sang Woo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Nitric oxide (NO) is an important signaling molecule involved in nociceptive transmission.
It can induce analgesic and hyperalgesic effects in the central nervous system.
In this study, patch-clamp recording was used to investigate the effect of NO on neuronal excitability in substantia gelatinosa (SG) neurons of the spinal cord.
Different concentrations of sodium nitroprusside (SNP; NO donor) induced a dual effect on the excitability of neuronal membrane: 1 mM of SNP evoked membrane hyperpolarization and an outward current, whereas 10 µM induced depolarization of the membrane and an inward current.
These effects were prevented by hemoglobin and 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt (c-PTIO) (NO scavengers), phenyl N-tert-butylnitrone (PBN; nonspecific reactive oxygen species scavenger), and through inhibition of soluble guanylyl cyclase (sGC).
Pretreatment with n-ethylmaleimide (NEM; thiol-alkylating agent) also decreased effects of both 1 mM and 10 µM SNP, suggesting that these responses were mediated by direct S-nitrosylation.
Charybdotoxin (CTX) and tetraethylammonium (TEA) (large-conductance Ca2+-activated K+ channel blockers) and glybenclamide (ATP-sensitive K+ channel blocker) decreased SNP-induced hyperpolarization.
La3+ (nonspecific cation channel blocker), but not Cs+ (hyperpolarization-activated K+ channel blocker), blocked SNP-induced membrane depolarization.
In conclusion, NO dually affects neuronal excitability in a concentration-dependent manner via modification of various K+ channels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, A-Reum& Lee, Hae In& Semjid, Dejidnorov& Kim, Do Kyung& Chun, Sang Woo. 2014. Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons. Neural Plasticity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046729
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, A-Reum…[et al.]. Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons. Neural Plasticity No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1046729
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, A-Reum& Lee, Hae In& Semjid, Dejidnorov& Kim, Do Kyung& Chun, Sang Woo. Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046729
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046729
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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