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Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia
المؤلفون المشاركون
Lucassen, Paul
Doorn, Karlijn J.
van Dam, Anne-Marie
Drukarch, B.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Besides dopamine-deficiency related motor symptoms, nonmotor symptoms, including cognitive changes occur in Parkinson's disease (PD) patients, that may relate to accumulation of α-synuclein in the hippocampus (HC).
This brain region also contains stem cells that can proliferate.
This is a well-regulated process that can, for example, be altered by neurodegenerative conditions.
In contrast to proliferation in the substantia nigra and subventricular zone, little is known about the HC in PD.
In addition, glial cells contribute to neurodegenerative processes and may proliferate in response to PD pathology.
In the present study, we questioned whether microglial cells proliferate in the HC of established PD patients versus control subjects or incidental Lewy body disease (iLBD) cases as a prodromal state of PD.
To this end, proliferation was assessed using the immunocytochemical marker minichromosome maintenance protein 2 (MCM2).
Colocalization with Iba1 was performed to determine microglial proliferation.
MCM2-positive cells were present in the HC of controls and were significantly increased in the presymptomatic iLBD cases, but not in established PD patients.
Microglia represented the majority of the proliferating cells in the HC.
This suggests an early microglial response to developing PD pathology in the HC and further indicates that neuroinflammatory processes play an important role in the development of PD pathology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Doorn, Karlijn J.& Drukarch, B.& van Dam, Anne-Marie& Lucassen, Paul. 2014. Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Doorn, Karlijn J.…[et al.]. Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1046754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Doorn, Karlijn J.& Drukarch, B.& van Dam, Anne-Marie& Lucassen, Paul. Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046754
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