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Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia
Joint Authors
Lucassen, Paul
Doorn, Karlijn J.
van Dam, Anne-Marie
Drukarch, B.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Besides dopamine-deficiency related motor symptoms, nonmotor symptoms, including cognitive changes occur in Parkinson's disease (PD) patients, that may relate to accumulation of α-synuclein in the hippocampus (HC).
This brain region also contains stem cells that can proliferate.
This is a well-regulated process that can, for example, be altered by neurodegenerative conditions.
In contrast to proliferation in the substantia nigra and subventricular zone, little is known about the HC in PD.
In addition, glial cells contribute to neurodegenerative processes and may proliferate in response to PD pathology.
In the present study, we questioned whether microglial cells proliferate in the HC of established PD patients versus control subjects or incidental Lewy body disease (iLBD) cases as a prodromal state of PD.
To this end, proliferation was assessed using the immunocytochemical marker minichromosome maintenance protein 2 (MCM2).
Colocalization with Iba1 was performed to determine microglial proliferation.
MCM2-positive cells were present in the HC of controls and were significantly increased in the presymptomatic iLBD cases, but not in established PD patients.
Microglia represented the majority of the proliferating cells in the HC.
This suggests an early microglial response to developing PD pathology in the HC and further indicates that neuroinflammatory processes play an important role in the development of PD pathology.
American Psychological Association (APA)
Doorn, Karlijn J.& Drukarch, B.& van Dam, Anne-Marie& Lucassen, Paul. 2014. Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046754
Modern Language Association (MLA)
Doorn, Karlijn J.…[et al.]. Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1046754
American Medical Association (AMA)
Doorn, Karlijn J.& Drukarch, B.& van Dam, Anne-Marie& Lucassen, Paul. Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046754