Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy
المؤلفون المشاركون
Gamal, Maha
Abdel Wahab, Zainab
Eshra, Mohamed
Rashed, Laila
Sharawy, Nivin
المصدر
Neurology Research International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Encephalopathy and brain edema are serious complications of acute liver injury and may lead to rapid death of patients.
The present study was designed to investigate the role of the inflammatory mediators and oxidative stress in the cytotoxic brain oedema and the neuroprotective effects of both minocycline and dexamethasone.
Methods.
48 male albino rats were divided into 4 groups: control group, acute liver injury (ALI) group, minocycline pretreated ALI group, and dexamethasone pretreated ALI group.
24 hours after acute liver injury serum ammonia, liver enzymes, brain levels of heme oxygenase-1 gene, iNOS gene expression, nitrite/nitrate, and cytokines were measured.
In addition, the grades of encephalopathy and brain water content were assessed.
Results.
ALI was associated with significant increases in all measured inflammatory mediators, oxidative stress, iNOS gene expression, and nitrite/nitrate.
Both minocycline and dexamethasone significantly modulated the inflammatory changes and the oxidative/nitrosative stress associated with ALI.
However, only minocycline but not dexamethasone significantly reduced the cytotoxic brain oedema.
Conclusion.
Both minocycline and dexamethasone could modulate inflammatory and oxidative changes observed in brain after ALI and could be novel preventative therapy for hepatic encephalopathy episodes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gamal, Maha& Abdel Wahab, Zainab& Eshra, Mohamed& Rashed, Laila& Sharawy, Nivin. 2014. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy. Neurology Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046769
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gamal, Maha…[et al.]. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy. Neurology Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046769
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gamal, Maha& Abdel Wahab, Zainab& Eshra, Mohamed& Rashed, Laila& Sharawy, Nivin. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046769
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046769
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر