Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy
Joint Authors
Gamal, Maha
Abdel Wahab, Zainab
Eshra, Mohamed
Rashed, Laila
Sharawy, Nivin
Source
Neurology Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Encephalopathy and brain edema are serious complications of acute liver injury and may lead to rapid death of patients.
The present study was designed to investigate the role of the inflammatory mediators and oxidative stress in the cytotoxic brain oedema and the neuroprotective effects of both minocycline and dexamethasone.
Methods.
48 male albino rats were divided into 4 groups: control group, acute liver injury (ALI) group, minocycline pretreated ALI group, and dexamethasone pretreated ALI group.
24 hours after acute liver injury serum ammonia, liver enzymes, brain levels of heme oxygenase-1 gene, iNOS gene expression, nitrite/nitrate, and cytokines were measured.
In addition, the grades of encephalopathy and brain water content were assessed.
Results.
ALI was associated with significant increases in all measured inflammatory mediators, oxidative stress, iNOS gene expression, and nitrite/nitrate.
Both minocycline and dexamethasone significantly modulated the inflammatory changes and the oxidative/nitrosative stress associated with ALI.
However, only minocycline but not dexamethasone significantly reduced the cytotoxic brain oedema.
Conclusion.
Both minocycline and dexamethasone could modulate inflammatory and oxidative changes observed in brain after ALI and could be novel preventative therapy for hepatic encephalopathy episodes.
American Psychological Association (APA)
Gamal, Maha& Abdel Wahab, Zainab& Eshra, Mohamed& Rashed, Laila& Sharawy, Nivin. 2014. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy. Neurology Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046769
Modern Language Association (MLA)
Gamal, Maha…[et al.]. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy. Neurology Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046769
American Medical Association (AMA)
Gamal, Maha& Abdel Wahab, Zainab& Eshra, Mohamed& Rashed, Laila& Sharawy, Nivin. Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046769