The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women
المؤلفون المشاركون
Ancheta, Irma B.
Battie, Cynthia A.
Richard, Dan
Ancheta, Christine V.
Borja-Hart, Nancy
Volgman, Annabelle S.
Conley, Yvette
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n = 235 ) participating in health screenings in four cities.
The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure.
The risk allele Trp719Arg was present in 77% of the subjects.
The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg.
Genotype did not predict the presence of CHD risk factors.
Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype.
However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level ( P < 0.01 ).
Approximately 60% of participants regardless of genotype exhibited LDL-C levels ≥ 100 mg/dL but were not taking medication.
Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels.
Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment.
Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ancheta, Irma B.& Battie, Cynthia A.& Richard, Dan& Ancheta, Christine V.& Borja-Hart, Nancy& Volgman, Annabelle S.…[et al.]. 2014. The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women. Nursing Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ancheta, Irma B.…[et al.]. The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women. Nursing Research and Practice Vol. 2014, no. 2014 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1046834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ancheta, Irma B.& Battie, Cynthia A.& Richard, Dan& Ancheta, Christine V.& Borja-Hart, Nancy& Volgman, Annabelle S.…[et al.]. The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women. Nursing Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر