The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women

Abstract EN

The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n = 235 ) participating in health screenings in four cities.

The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure.

The risk allele Trp719Arg was present in 77% of the subjects.

The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg.

Genotype did not predict the presence of CHD risk factors.

Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype.

However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level ( P < 0.01 ).

Approximately 60% of participants regardless of genotype exhibited LDL-C levels ≥ 100 mg/dL but were not taking medication.

Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels.

Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment.

Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs.