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In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism
المؤلفون المشاركون
Areias, M. J.
Matos, Andreia
Pereira da Silva, Alda
Clara Bicho, Maria
Afonso, Conceição
Bicho, Manuel
Rebelo, Irene
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Preeclampsia (PE) may affect the risk for future cardiovascular disease.
Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes.
We performed a prospective study in 352 women aged 35 ± 5.48 years, which 165 had previous PE, 2 to 16 years ago.
We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B).
Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis.
Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism.
The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matos, Andreia& Pereira da Silva, Alda& Clara Bicho, Maria& Afonso, Conceição& Areias, M. J.& Rebelo, Irene…[et al.]. 2014. In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism. Obstetrics and Gynecology International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046891
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matos, Andreia…[et al.]. In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism. Obstetrics and Gynecology International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046891
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matos, Andreia& Pereira da Silva, Alda& Clara Bicho, Maria& Afonso, Conceição& Areias, M. J.& Rebelo, Irene…[et al.]. In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism. Obstetrics and Gynecology International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046891
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046891
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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