In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism
Joint Authors
Areias, M. J.
Matos, Andreia
Pereira da Silva, Alda
Clara Bicho, Maria
Afonso, Conceição
Bicho, Manuel
Rebelo, Irene
Source
Obstetrics and Gynecology International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Preeclampsia (PE) may affect the risk for future cardiovascular disease.
Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes.
We performed a prospective study in 352 women aged 35 ± 5.48 years, which 165 had previous PE, 2 to 16 years ago.
We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B).
Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis.
Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism.
The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.
American Psychological Association (APA)
Matos, Andreia& Pereira da Silva, Alda& Clara Bicho, Maria& Afonso, Conceição& Areias, M. J.& Rebelo, Irene…[et al.]. 2014. In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism. Obstetrics and Gynecology International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046891
Modern Language Association (MLA)
Matos, Andreia…[et al.]. In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism. Obstetrics and Gynecology International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046891
American Medical Association (AMA)
Matos, Andreia& Pereira da Silva, Alda& Clara Bicho, Maria& Afonso, Conceição& Areias, M. J.& Rebelo, Irene…[et al.]. In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism. Obstetrics and Gynecology International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046891