Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts
المؤلفون المشاركون
Wang, Yanming
Zheng, Qiusheng
Wang, Dong
Han, Jichun
Yu, Bacui
Ren, Huanhuan
Zhang, Bo
Wang, Yonghua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The generation of reactive oxygen species (ROS) is a major cause of heart injury induced by ischemia-reperfusion.
The left ventricular developed pressure (LVDP) and the maximum up/down rate of left ventricular pressure ( ± d p / d t max ) were documented by a physiological recorder.
Myocardial infarct size was estimated macroscopically using 2,3,5-triphenyltetrazolium chloride staining.
Coronary effluent was analyzed for lactate dehydrogenase (LDH) and creatine kinase (CK) release to assess the degree of cardiac injury.
The levels of C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were analyzed to determine the inflammation status of the myocardial tissue.
Cardiomyocyte apoptosis analysis was performed using the In Situ Cell Death Detection Kit, POD.
Accordingly, licochalcone B pretreatment improved the heart rate (HR), increased LVDP, and decreased CK and LDH levels in coronary flow.
SOD level and GSH/GSSG ratio increased, whereas the levels of MDA, TNF-α, and CRP and activities of IL-8 and IL-6 decreased in licochalcone B-treated groups.
The infarct size and cell apoptosis in hearts from licochalcone B-treated group were lower than those in hearts from the I/R control group.
Therefore, the cardioprotective effects of licochalcone B may be attributed to its antioxidant, antiapoptotic, and anti-inflammatory activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Jichun& Wang, Dong& Yu, Bacui& Wang, Yanming& Ren, Huanhuan& Zhang, Bo…[et al.]. 2014. Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046929
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Jichun…[et al.]. Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1046929
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Jichun& Wang, Dong& Yu, Bacui& Wang, Yanming& Ren, Huanhuan& Zhang, Bo…[et al.]. Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046929
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046929
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر