Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts
Joint Authors
Wang, Yanming
Zheng, Qiusheng
Wang, Dong
Han, Jichun
Yu, Bacui
Ren, Huanhuan
Zhang, Bo
Wang, Yonghua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The generation of reactive oxygen species (ROS) is a major cause of heart injury induced by ischemia-reperfusion.
The left ventricular developed pressure (LVDP) and the maximum up/down rate of left ventricular pressure ( ± d p / d t max ) were documented by a physiological recorder.
Myocardial infarct size was estimated macroscopically using 2,3,5-triphenyltetrazolium chloride staining.
Coronary effluent was analyzed for lactate dehydrogenase (LDH) and creatine kinase (CK) release to assess the degree of cardiac injury.
The levels of C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were analyzed to determine the inflammation status of the myocardial tissue.
Cardiomyocyte apoptosis analysis was performed using the In Situ Cell Death Detection Kit, POD.
Accordingly, licochalcone B pretreatment improved the heart rate (HR), increased LVDP, and decreased CK and LDH levels in coronary flow.
SOD level and GSH/GSSG ratio increased, whereas the levels of MDA, TNF-α, and CRP and activities of IL-8 and IL-6 decreased in licochalcone B-treated groups.
The infarct size and cell apoptosis in hearts from licochalcone B-treated group were lower than those in hearts from the I/R control group.
Therefore, the cardioprotective effects of licochalcone B may be attributed to its antioxidant, antiapoptotic, and anti-inflammatory activities.
American Psychological Association (APA)
Han, Jichun& Wang, Dong& Yu, Bacui& Wang, Yanming& Ren, Huanhuan& Zhang, Bo…[et al.]. 2014. Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046929
Modern Language Association (MLA)
Han, Jichun…[et al.]. Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1046929
American Medical Association (AMA)
Han, Jichun& Wang, Dong& Yu, Bacui& Wang, Yanming& Ren, Huanhuan& Zhang, Bo…[et al.]. Cardioprotection against IschemiaReperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1046929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046929