The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model
المؤلفون المشاركون
Fan, Zhe
Jing, Huirong
Yao, Jihong
Li, Yang
Hu, Xiaowei
Shao, Huizhu
Shen, Gang
Pan, Jiyong
Luo, Fuwen
Tian, Xiaofeng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia/reperfusion (I/R), which induces an acute liver lesion.
Methods.
Curcumin was injected into rats in the curcumin groups through left femoral vein.
The same volume of vehicle (0.9% normal saline) was injected into sham and I/R groups.
Blood and liver tissue were gathered for serological and histopathological determination.
Results.
Intestinal I/R led to severe liver injury manifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin.
Simultaneously, the activity of SOD in liver decreased after intestinal I/R, which was increased by curcumin treatment.
On the other hand, curcumin reduced MPO activity of liver tissue, as well as serum IL-6 and TNF-α levels observably.
This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) expression.
Conclusion.
Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-κB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Zhe& Jing, Huirong& Yao, Jihong& Li, Yang& Hu, Xiaowei& Shao, Huizhu…[et al.]. 2014. The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Zhe…[et al.]. The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Zhe& Jing, Huirong& Yao, Jihong& Li, Yang& Hu, Xiaowei& Shao, Huizhu…[et al.]. The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر