The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model
Joint Authors
Fan, Zhe
Jing, Huirong
Yao, Jihong
Li, Yang
Hu, Xiaowei
Shao, Huizhu
Shen, Gang
Pan, Jiyong
Luo, Fuwen
Tian, Xiaofeng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia/reperfusion (I/R), which induces an acute liver lesion.
Methods.
Curcumin was injected into rats in the curcumin groups through left femoral vein.
The same volume of vehicle (0.9% normal saline) was injected into sham and I/R groups.
Blood and liver tissue were gathered for serological and histopathological determination.
Results.
Intestinal I/R led to severe liver injury manifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin.
Simultaneously, the activity of SOD in liver decreased after intestinal I/R, which was increased by curcumin treatment.
On the other hand, curcumin reduced MPO activity of liver tissue, as well as serum IL-6 and TNF-α levels observably.
This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) expression.
Conclusion.
Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-κB pathway.
American Psychological Association (APA)
Fan, Zhe& Jing, Huirong& Yao, Jihong& Li, Yang& Hu, Xiaowei& Shao, Huizhu…[et al.]. 2014. The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046955
Modern Language Association (MLA)
Fan, Zhe…[et al.]. The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046955
American Medical Association (AMA)
Fan, Zhe& Jing, Huirong& Yao, Jihong& Li, Yang& Hu, Xiaowei& Shao, Huizhu…[et al.]. The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046955