Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
المؤلفون المشاركون
Khaper, Neelam
Belló-Klein, Adriane
Araujo, Alex Sander da Rosa
Campos, Cristina
Casali, Karina Rabello
Baraldi, Dhãniel
Conzatti, Adriana
Llesuy, Susana
Rigatto, Katya
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress.
Female Wistar rats (n=9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously.
Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed.
Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured.
HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability.
These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT.
A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group.
Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Campos, Cristina& Casali, Karina Rabello& Baraldi, Dhãniel& Conzatti, Adriana& Araujo, Alex Sander da Rosa& Khaper, Neelam…[et al.]. 2014. Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Campos, Cristina…[et al.]. Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Campos, Cristina& Casali, Karina Rabello& Baraldi, Dhãniel& Conzatti, Adriana& Araujo, Alex Sander da Rosa& Khaper, Neelam…[et al.]. Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر