Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability
Joint Authors
Khaper, Neelam
Belló-Klein, Adriane
Araujo, Alex Sander da Rosa
Campos, Cristina
Casali, Karina Rabello
Baraldi, Dhãniel
Conzatti, Adriana
Llesuy, Susana
Rigatto, Katya
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study tested whether a low dose (40% less than the pharmacological dose of 17-β estradiol) would be as effective as the pharmacological dose to improve cardiovascular parameters and decrease cardiac oxidative stress.
Female Wistar rats (n=9/group) were divided in three groups: (1) ovariectomized (Ovx), (2) ovariectomized animals treated for 21 days with low dose (LE; 0.2 mg), and (3) high dose (HE; 0.5 mg) 17-β estradiol subcutaneously.
Hemodynamic assessment and spectral analysis for evaluation of autonomic nervous system regulation were performed.
Myocardial superoxide dismutase (SOD) and catalase (CAT) activities, redox ratio (GSH/GSSG), total radical-trapping antioxidant potential (TRAP), hydrogen peroxide, and superoxide anion concentrations were measured.
HE and LE groups exhibited an improvement in hemodynamic function and heart rate variability.
These changes were associated with an increase in the TRAP, GSH/GSSG, SOD, and CAT.
A decrease in hydrogen peroxide and superoxide anion was also observed in the treated estrogen groups as compared to the Ovx group.
Our results indicate that a low dose of estrogen is just as effective as a high dose into promoting cardiovascular function and reducing oxidative stress, thereby supporting the approach of using low dose of estrogen in clinical settings to minimize the risks associated with estrogen therapy.
American Psychological Association (APA)
Campos, Cristina& Casali, Karina Rabello& Baraldi, Dhãniel& Conzatti, Adriana& Araujo, Alex Sander da Rosa& Khaper, Neelam…[et al.]. 2014. Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046974
Modern Language Association (MLA)
Campos, Cristina…[et al.]. Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046974
American Medical Association (AMA)
Campos, Cristina& Casali, Karina Rabello& Baraldi, Dhãniel& Conzatti, Adriana& Araujo, Alex Sander da Rosa& Khaper, Neelam…[et al.]. Efficacy of a Low Dose of Estrogen on Antioxidant Defenses and Heart Rate Variability. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046974