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Vitamin A Supplementation Alleviates Extrahepatic Cholestasis Liver Injury through Nrf2 Activation
المؤلفون المشاركون
Wang, Guiyang
Xiu, Peng
Li, Fu
Xin, Cheng
Li, Kewei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To investigate the role of vitamin A in liver damage induced by bile duct ligation (BDL) in rats.
Methods.
Thirty male Wistar rats were randomly divided into three groups: SHAM group, BDL group, and BDL + VitA group .
The concentrations of retinol and retinyl palmitate in the liver were analyzed using HPLC, and liver function was evaluated by the level of TBIL, ALT, AST, and ALP in serum.
Hepatic oxidative status was estimated by measuring T-SOD, CAT, GSH, MDA, and AOPP.
Nrf2 expression was assessed using immunohistochemistry and western blotting, and EMSA was performed to determine Nrf2 DNA-binding activity.
The expression of the downstream factors such as Ho1 and Nqo1 was also examined using immunohistochemistry and western blotting assays.
Results.
Vitamin A treatment restored levels of retinoids in liver, improved liver function, alleviated oxidative stress, and facilitated the translocation of Nrf2 to the nucleus in the experimental obstructive jaundice.
Vitamin A was also found to increase the expression of Nrf2 downstream proteins such as Ho1 and Nqo1.
Conclusion.
Vitamin A was here found to ameliorate cholestatic liver injury.
This effect may be related to the activation of Nrf2/ARE pathway in bile duct ligation rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Guiyang& Xiu, Peng& Li, Fu& Xin, Cheng& Li, Kewei. 2014. Vitamin A Supplementation Alleviates Extrahepatic Cholestasis Liver Injury through Nrf2 Activation. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Guiyang…[et al.]. Vitamin A Supplementation Alleviates Extrahepatic Cholestasis Liver Injury through Nrf2 Activation. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Guiyang& Xiu, Peng& Li, Fu& Xin, Cheng& Li, Kewei. Vitamin A Supplementation Alleviates Extrahepatic Cholestasis Liver Injury through Nrf2 Activation. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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