![](/images/graphics-bg.png)
Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation
المؤلفون المشاركون
Kremláček, J.
Borska, Lenka
Palicka, Vladimir
Chmelarova, Marcela
Hamakova, Kvetoslava
Fiala, Zdenek
Krejsek, Jan
Andrys, Ctirad
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The paper presents a prospective cohort study.
Observed group was formed of children with plaque psoriasis ( n=19 ) treated by Goeckerman therapy (GT).
The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation).
After GT we found significantly increased markers of oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes.
We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts.
The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment.
However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system.
The study confirmed good effectiveness of the GT (significantly decreased PASI score).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Borska, Lenka& Andrys, Ctirad& Krejsek, Jan& Palicka, Vladimir& Chmelarova, Marcela& Hamakova, Kvetoslava…[et al.]. 2014. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Borska, Lenka…[et al.]. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Borska, Lenka& Andrys, Ctirad& Krejsek, Jan& Palicka, Vladimir& Chmelarova, Marcela& Hamakova, Kvetoslava…[et al.]. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)