![](/images/graphics-bg.png)
Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation
Joint Authors
Kremláček, J.
Borska, Lenka
Palicka, Vladimir
Chmelarova, Marcela
Hamakova, Kvetoslava
Fiala, Zdenek
Krejsek, Jan
Andrys, Ctirad
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The paper presents a prospective cohort study.
Observed group was formed of children with plaque psoriasis ( n=19 ) treated by Goeckerman therapy (GT).
The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation).
After GT we found significantly increased markers of oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes.
We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts.
The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment.
However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system.
The study confirmed good effectiveness of the GT (significantly decreased PASI score).
American Psychological Association (APA)
Borska, Lenka& Andrys, Ctirad& Krejsek, Jan& Palicka, Vladimir& Chmelarova, Marcela& Hamakova, Kvetoslava…[et al.]. 2014. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046999
Modern Language Association (MLA)
Borska, Lenka…[et al.]. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046999
American Medical Association (AMA)
Borska, Lenka& Andrys, Ctirad& Krejsek, Jan& Palicka, Vladimir& Chmelarova, Marcela& Hamakova, Kvetoslava…[et al.]. Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046999