Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways
المؤلفون المشاركون
Li, Ying-Na
Guo, Yu
Yang, Pei
Zhou, Xue-Ying
Yin, Shuang
Hai, Chun-Xu
Li, Jin-Gang
Qin, Xu-Jun
Xi, Miao-Miao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Reactive oxygen species (ROS) are closely related to the aging process.
In our previous studies, we found that the saponins from Aralia taibaiensis have potent antioxidant activity, suggesting the potential protective activity on the aging.
However, the protective effect of the saponins and the possible underlying molecular mechanism remain unknown.
In the present study, we employed a D-galactose-induced aging rat model to investigate the protective effect of the saponins.
We found that D-galactose treatment induced obvious aging-related changes such as the decreased thymus and spleen coefficients, the increased advanced glycation end products (AGEs) level, senescence-associated β-galactosidase (SAβ-gal) activity, and malondialdehyde (MDA) level.
Further results showed that Forkhead box O3a (FOXO3a), nuclear factor-erythroid 2-related factor 2 (Nrf2), and their targeted antioxidants such as superoxide dismutase 2 (SOD2), catalase (CAT), glutathione reductase (GR), glutathione (GSH), glutamate-cysteine ligase (GCL), and heme oxygenase 1 (HO-1) were all inhibited in the aging rats induced by D-galactose treatment.
Saponins supplementation showed effective protection on these changes.
These results demonstrate that saponins from Aralia taibaiensis attenuate the D-galactose-induced rat aging.
By activating FOXO3a and Nrf2 pathways, saponins increase their downstream multiple antioxidants expression and function, at least in part contributing to the protection on the D-galactose-induced aging in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Ying-Na& Guo, Yu& Xi, Miao-Miao& Yang, Pei& Zhou, Xue-Ying& Yin, Shuang…[et al.]. 2013. Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047010
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Ying-Na…[et al.]. Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047010
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Ying-Na& Guo, Yu& Xi, Miao-Miao& Yang, Pei& Zhou, Xue-Ying& Yin, Shuang…[et al.]. Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047010
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047010
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر