Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways
Joint Authors
Li, Ying-Na
Guo, Yu
Yang, Pei
Zhou, Xue-Ying
Yin, Shuang
Hai, Chun-Xu
Li, Jin-Gang
Qin, Xu-Jun
Xi, Miao-Miao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Reactive oxygen species (ROS) are closely related to the aging process.
In our previous studies, we found that the saponins from Aralia taibaiensis have potent antioxidant activity, suggesting the potential protective activity on the aging.
However, the protective effect of the saponins and the possible underlying molecular mechanism remain unknown.
In the present study, we employed a D-galactose-induced aging rat model to investigate the protective effect of the saponins.
We found that D-galactose treatment induced obvious aging-related changes such as the decreased thymus and spleen coefficients, the increased advanced glycation end products (AGEs) level, senescence-associated β-galactosidase (SAβ-gal) activity, and malondialdehyde (MDA) level.
Further results showed that Forkhead box O3a (FOXO3a), nuclear factor-erythroid 2-related factor 2 (Nrf2), and their targeted antioxidants such as superoxide dismutase 2 (SOD2), catalase (CAT), glutathione reductase (GR), glutathione (GSH), glutamate-cysteine ligase (GCL), and heme oxygenase 1 (HO-1) were all inhibited in the aging rats induced by D-galactose treatment.
Saponins supplementation showed effective protection on these changes.
These results demonstrate that saponins from Aralia taibaiensis attenuate the D-galactose-induced rat aging.
By activating FOXO3a and Nrf2 pathways, saponins increase their downstream multiple antioxidants expression and function, at least in part contributing to the protection on the D-galactose-induced aging in rats.
American Psychological Association (APA)
Li, Ying-Na& Guo, Yu& Xi, Miao-Miao& Yang, Pei& Zhou, Xue-Ying& Yin, Shuang…[et al.]. 2013. Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047010
Modern Language Association (MLA)
Li, Ying-Na…[et al.]. Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047010
American Medical Association (AMA)
Li, Ying-Na& Guo, Yu& Xi, Miao-Miao& Yang, Pei& Zhou, Xue-Ying& Yin, Shuang…[et al.]. Saponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047010