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Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload
المؤلفون المشاركون
Štikarová, Jana
Kotlín, Roman
Pimková, Kristýna
Chrastinová, Leona
Dyr, Jan Evangelista
Suttnar, Jiri
Cermak, Jaroslav
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The role of oxidative stress in the initiation and progression of myelodysplastic syndromes (MDS) as a consequence of iron overload remains unclear.
In this study we have simultaneously quantified plasma low-molecular-weight aminothiols, malondialdehyde, nitrite, and nitrate and have studied their correlation with serum iron/ferritin levels, patient treatment (chelation therapy), and clinical outcomes.
We found significantly elevated plasma levels of total, oxidized, and reduced forms of cysteine P < 0.001 , homocysteine P < 0.001 , and cysteinylglycine P < 0.006 and significantly depressed levels of total and oxidized forms of glutathione P < 0.03 and nitrite P < 0.001 in MDS patients compared to healthy donors.
Moreover, total ( P = 0.032 ) and oxidized cysteinylglycine ( P = 0.029 ) and nitrite ( P = 0.021 ) differed significantly between the analyzed MDS subgroups with different clinical classifications.
Malondialdehyde levels in plasma correlated moderately with both serum ferritin levels ( r = 0.78 , P = 0.001 ) and serum free iron levels ( r = 0.60 , P = 0.001 ) and were significantly higher in patients with iron overload.
The other analyzed compounds lacked correlation with iron overload (represented by serum iron/ferritin levels).
For the first time our results have revealed significant differences in the concentrations of plasma aminothiols in MDS patients, when compared to healthy donors.
We found no correlation of these parameters with iron overload and suggest the role of oxidative stress in the development of MDS disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pimková, Kristýna& Chrastinová, Leona& Suttnar, Jiri& Štikarová, Jana& Kotlín, Roman& Cermak, Jaroslav…[et al.]. 2014. Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pimková, Kristýna…[et al.]. Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pimková, Kristýna& Chrastinová, Leona& Suttnar, Jiri& Štikarová, Jana& Kotlín, Roman& Cermak, Jaroslav…[et al.]. Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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