Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload
Joint Authors
Štikarová, Jana
Kotlín, Roman
Pimková, Kristýna
Chrastinová, Leona
Dyr, Jan Evangelista
Suttnar, Jiri
Cermak, Jaroslav
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The role of oxidative stress in the initiation and progression of myelodysplastic syndromes (MDS) as a consequence of iron overload remains unclear.
In this study we have simultaneously quantified plasma low-molecular-weight aminothiols, malondialdehyde, nitrite, and nitrate and have studied their correlation with serum iron/ferritin levels, patient treatment (chelation therapy), and clinical outcomes.
We found significantly elevated plasma levels of total, oxidized, and reduced forms of cysteine P < 0.001 , homocysteine P < 0.001 , and cysteinylglycine P < 0.006 and significantly depressed levels of total and oxidized forms of glutathione P < 0.03 and nitrite P < 0.001 in MDS patients compared to healthy donors.
Moreover, total ( P = 0.032 ) and oxidized cysteinylglycine ( P = 0.029 ) and nitrite ( P = 0.021 ) differed significantly between the analyzed MDS subgroups with different clinical classifications.
Malondialdehyde levels in plasma correlated moderately with both serum ferritin levels ( r = 0.78 , P = 0.001 ) and serum free iron levels ( r = 0.60 , P = 0.001 ) and were significantly higher in patients with iron overload.
The other analyzed compounds lacked correlation with iron overload (represented by serum iron/ferritin levels).
For the first time our results have revealed significant differences in the concentrations of plasma aminothiols in MDS patients, when compared to healthy donors.
We found no correlation of these parameters with iron overload and suggest the role of oxidative stress in the development of MDS disease.
American Psychological Association (APA)
Pimková, Kristýna& Chrastinová, Leona& Suttnar, Jiri& Štikarová, Jana& Kotlín, Roman& Cermak, Jaroslav…[et al.]. 2014. Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047025
Modern Language Association (MLA)
Pimková, Kristýna…[et al.]. Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047025
American Medical Association (AMA)
Pimková, Kristýna& Chrastinová, Leona& Suttnar, Jiri& Štikarová, Jana& Kotlín, Roman& Cermak, Jaroslav…[et al.]. Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047025