A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo
المؤلفون المشاركون
Liu, Tong-qiang
Luo, Wei-li
Tan, Xiao
Fang, Yi
Chen, Jing
Zhang, Hui
Yu, Xiao-fang
Cai, Jie-ru
Ding, Xiao-qiang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media.
Proper animal models of CI-AKI can help understand the mechanisms involved and prevent the disorder.
We used the 5/6-nephrectomized (NE) rat to develop a CI-AKI model and to evaluate differences in the toxic effects on the kidney between iohexol and iodixanol.
We found that six weeks after ablative surgery was the preferred time to induce CI-AKI.
We compared multiple pretreatment plans and found that dehydration for 48 hours before iodixanol (320, 10 mL/kg) administration was optimal to induce CI-AKI in the 5/6 NE rats.
Compared with iodixanol, iohexol induced a significantly greater reduction in renal function, severe renal tissue damage, intrarenal hypoxia, and apoptotic tubular cells.
Iohexol and iodixanol resulted in similarly marked increases in levels of inflammation and oxidative stress.
In summary, the 5/6 NE rat combined with dehydration for 48 hours is a useful pretreatment to establish a novel and reliable CI-AKI model.
Iohexol induced more severe CI-AKI than iodixanol in this model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Tong-qiang& Luo, Wei-li& Tan, Xiao& Fang, Yi& Chen, Jing& Zhang, Hui…[et al.]. 2014. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047030
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Tong-qiang…[et al.]. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047030
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Tong-qiang& Luo, Wei-li& Tan, Xiao& Fang, Yi& Chen, Jing& Zhang, Hui…[et al.]. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047030
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047030
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر