A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo
Joint Authors
Liu, Tong-qiang
Luo, Wei-li
Tan, Xiao
Fang, Yi
Chen, Jing
Zhang, Hui
Yu, Xiao-fang
Cai, Jie-ru
Ding, Xiao-qiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media.
Proper animal models of CI-AKI can help understand the mechanisms involved and prevent the disorder.
We used the 5/6-nephrectomized (NE) rat to develop a CI-AKI model and to evaluate differences in the toxic effects on the kidney between iohexol and iodixanol.
We found that six weeks after ablative surgery was the preferred time to induce CI-AKI.
We compared multiple pretreatment plans and found that dehydration for 48 hours before iodixanol (320, 10 mL/kg) administration was optimal to induce CI-AKI in the 5/6 NE rats.
Compared with iodixanol, iohexol induced a significantly greater reduction in renal function, severe renal tissue damage, intrarenal hypoxia, and apoptotic tubular cells.
Iohexol and iodixanol resulted in similarly marked increases in levels of inflammation and oxidative stress.
In summary, the 5/6 NE rat combined with dehydration for 48 hours is a useful pretreatment to establish a novel and reliable CI-AKI model.
Iohexol induced more severe CI-AKI than iodixanol in this model.
American Psychological Association (APA)
Liu, Tong-qiang& Luo, Wei-li& Tan, Xiao& Fang, Yi& Chen, Jing& Zhang, Hui…[et al.]. 2014. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047030
Modern Language Association (MLA)
Liu, Tong-qiang…[et al.]. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047030
American Medical Association (AMA)
Liu, Tong-qiang& Luo, Wei-li& Tan, Xiao& Fang, Yi& Chen, Jing& Zhang, Hui…[et al.]. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047030