A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo

Joint Authors

Liu, Tong-qiang
Luo, Wei-li
Tan, Xiao
Fang, Yi
Chen, Jing
Zhang, Hui
Yu, Xiao-fang
Cai, Jie-ru
Ding, Xiao-qiang

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-11-11

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Biology

Abstract EN

Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media.

Proper animal models of CI-AKI can help understand the mechanisms involved and prevent the disorder.

We used the 5/6-nephrectomized (NE) rat to develop a CI-AKI model and to evaluate differences in the toxic effects on the kidney between iohexol and iodixanol.

We found that six weeks after ablative surgery was the preferred time to induce CI-AKI.

We compared multiple pretreatment plans and found that dehydration for 48 hours before iodixanol (320, 10 mL/kg) administration was optimal to induce CI-AKI in the 5/6 NE rats.

Compared with iodixanol, iohexol induced a significantly greater reduction in renal function, severe renal tissue damage, intrarenal hypoxia, and apoptotic tubular cells.

Iohexol and iodixanol resulted in similarly marked increases in levels of inflammation and oxidative stress.

In summary, the 5/6 NE rat combined with dehydration for 48 hours is a useful pretreatment to establish a novel and reliable CI-AKI model.

Iohexol induced more severe CI-AKI than iodixanol in this model.

American Psychological Association (APA)

Liu, Tong-qiang& Luo, Wei-li& Tan, Xiao& Fang, Yi& Chen, Jing& Zhang, Hui…[et al.]. 2014. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047030

Modern Language Association (MLA)

Liu, Tong-qiang…[et al.]. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047030

American Medical Association (AMA)

Liu, Tong-qiang& Luo, Wei-li& Tan, Xiao& Fang, Yi& Chen, Jing& Zhang, Hui…[et al.]. A Novel Contrast-Induced Acute Kidney Injury Model Based on the 56-Nephrectomy Rat and Nephrotoxicological Evaluation of Iohexol and Iodixanol In Vivo. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047030

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1047030