Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity
المؤلفون المشاركون
da Rocha, João Batista Teixeira
Pessoa-Pureur, Regina
Heimfarth, Luana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-22
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Evidence from our group supports that diphenyl ditelluride (PhTe)2 neurotoxicity depends on modulation of signaling pathways initiated at the plasma membrane.
The (PhTe)2-evoked signal is transduced downstream of voltage-dependent Ca2+ channels (VDCC), N-methyl-D-aspartate receptors (NMDA), or metabotropic glutamate receptors activation via different kinase pathways (protein kinase A, phospholipase C/protein kinase C, mitogen-activated protein kinases (MAPKs), and Akt signaling pathway).
Among the most relevant cues of misregulated signaling mechanisms evoked by (PhTe)2 is the cytoskeleton of neural cells.
The in vivo and in vitro exposure to (PhTe)2 induce hyperphosphorylation/hypophosphorylation of neuronal and glial intermediate filament (IF) proteins (neurofilaments and glial fibrillary acidic protein, resp.) in different brain structures of young rats.
Phosphorylation of IFs at specific sites modulates their association/disassociation and interferes with important physiological roles, such as axonal transport.
Disrupted cytoskeleton is a crucial marker of neurodegeneration and is associated with reactive astrogliosis and apoptotic cell death.
This review focuses the current knowledge and important results on the mechanisms of (PhTe)2 neurotoxicity with special emphasis on the cytoskeletal proteins and their differential regulation by kinases/phosphatases and Ca2+-mediated mechanisms in developmental rat brain.
We propose that the disrupted cytoskeletal homeostasis could support brain damage provoked by this neurotoxicant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pessoa-Pureur, Regina& Heimfarth, Luana& da Rocha, João Batista Teixeira. 2014. Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1047038
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pessoa-Pureur, Regina…[et al.]. Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1047038
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pessoa-Pureur, Regina& Heimfarth, Luana& da Rocha, João Batista Teixeira. Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1047038
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047038
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر