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Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity
Joint Authors
da Rocha, João Batista Teixeira
Pessoa-Pureur, Regina
Heimfarth, Luana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Evidence from our group supports that diphenyl ditelluride (PhTe)2 neurotoxicity depends on modulation of signaling pathways initiated at the plasma membrane.
The (PhTe)2-evoked signal is transduced downstream of voltage-dependent Ca2+ channels (VDCC), N-methyl-D-aspartate receptors (NMDA), or metabotropic glutamate receptors activation via different kinase pathways (protein kinase A, phospholipase C/protein kinase C, mitogen-activated protein kinases (MAPKs), and Akt signaling pathway).
Among the most relevant cues of misregulated signaling mechanisms evoked by (PhTe)2 is the cytoskeleton of neural cells.
The in vivo and in vitro exposure to (PhTe)2 induce hyperphosphorylation/hypophosphorylation of neuronal and glial intermediate filament (IF) proteins (neurofilaments and glial fibrillary acidic protein, resp.) in different brain structures of young rats.
Phosphorylation of IFs at specific sites modulates their association/disassociation and interferes with important physiological roles, such as axonal transport.
Disrupted cytoskeleton is a crucial marker of neurodegeneration and is associated with reactive astrogliosis and apoptotic cell death.
This review focuses the current knowledge and important results on the mechanisms of (PhTe)2 neurotoxicity with special emphasis on the cytoskeletal proteins and their differential regulation by kinases/phosphatases and Ca2+-mediated mechanisms in developmental rat brain.
We propose that the disrupted cytoskeletal homeostasis could support brain damage provoked by this neurotoxicant.
American Psychological Association (APA)
Pessoa-Pureur, Regina& Heimfarth, Luana& da Rocha, João Batista Teixeira. 2014. Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1047038
Modern Language Association (MLA)
Pessoa-Pureur, Regina…[et al.]. Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1047038
American Medical Association (AMA)
Pessoa-Pureur, Regina& Heimfarth, Luana& da Rocha, João Batista Teixeira. Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1047038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047038