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RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells
المؤلفون المشاركون
Peiris, Heshan
Dubach, Daphne
Jessup, Claire F.
Unterweger, Petra
Raghupathi, Ravinarayan
Muyderman, Hakan
Zanin, Mark P.
Mackenzie, Kimberly
Pritchard, Melanie A.
Keating, Damien J.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Mitochondria are the primary site of cellular energy generation and reactive oxygen species (ROS) accumulation.
Elevated ROS levels are detrimental to normal cell function and have been linked to the pathogenesis of neurodegenerative disorders such as Down's syndrome (DS) and Alzheimer’s disease (AD).
RCAN1 is abundantly expressed in the brain and overexpressed in brain of DS and AD patients.
Data from nonmammalian species indicates that increased RCAN1 expression results in altered mitochondrial function and that RCAN1 may itself regulate neuronal ROS production.
In this study, we have utilized mice overexpressing RCAN1 R C A N 1 o x and demonstrate an increased susceptibility of neurons from these mice to oxidative stress.
Mitochondria from these mice are more numerous and smaller, indicative of mitochondrial dysfunction, and mitochondrial membrane potential is altered under conditions of oxidative stress.
We also generated a PC12 cell line overexpressing RCAN1 P C 12 R C A N 1 .
Similar to R C A N 1 o x neurons, P C 12 R C A N 1 cells have an increased susceptibility to oxidative stress and produce more mitochondrial ROS.
This study demonstrates that increasing RCAN1 expression alters mitochondrial function and increases the susceptibility of neurons to oxidative stress in mammalian cells.
These findings further contribute to our understanding of RCAN1 and its potential role in the pathogenesis of neurodegenerative disorders such as AD and DS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peiris, Heshan& Dubach, Daphne& Jessup, Claire F.& Unterweger, Petra& Raghupathi, Ravinarayan& Muyderman, Hakan…[et al.]. 2014. RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peiris, Heshan…[et al.]. RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1047051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peiris, Heshan& Dubach, Daphne& Jessup, Claire F.& Unterweger, Petra& Raghupathi, Ravinarayan& Muyderman, Hakan…[et al.]. RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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