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The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury
المؤلفون المشاركون
Kang, So Mang
Lee, Kyoung Min
Lee, Won Taek
Song, Juhyun
Park, Kyung Ah
Lee, Jong Eun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-13
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Melatonin has a cellular protective effect in cerebrovascular and neurodegenerative diseases.
Protection of brain endothelial cells against hypoxia and oxidative stress is important for treatment of central nervous system (CNS) diseases, since brain endothelial cells constitute the blood brain barrier (BBB).
In the present study, we investigated the protective effect of melatonin against oxygen-glucose deprivation, followed by reperfusion- (OGD/R-) induced injury, in bEnd.3 cells.
The effect of melatonin was examined by western blot analysis, cell viability assays, measurement of intracellular reactive oxygen species (ROS), and immunocytochemistry (ICC).
Our results showed that treatment with melatonin prevents cell death and degradation of tight junction protein in the setting of OGD/R-induced injury.
In response to OGD/R injury of bEnd.3 cells, melatonin activates Akt, which promotes cell survival, and attenuates phosphorylation of JNK, which triggers apoptosis.
Thus, melatonin protects bEnd.3 cells against OGD/R-induced injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Juhyun& Kang, So Mang& Lee, Won Taek& Park, Kyung Ah& Lee, Kyoung Min& Lee, Jong Eun. 2014. The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Juhyun…[et al.]. The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Juhyun& Kang, So Mang& Lee, Won Taek& Park, Kyung Ah& Lee, Kyoung Min& Lee, Jong Eun. The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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