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The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury
Joint Authors
Kang, So Mang
Lee, Kyoung Min
Lee, Won Taek
Song, Juhyun
Park, Kyung Ah
Lee, Jong Eun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Melatonin has a cellular protective effect in cerebrovascular and neurodegenerative diseases.
Protection of brain endothelial cells against hypoxia and oxidative stress is important for treatment of central nervous system (CNS) diseases, since brain endothelial cells constitute the blood brain barrier (BBB).
In the present study, we investigated the protective effect of melatonin against oxygen-glucose deprivation, followed by reperfusion- (OGD/R-) induced injury, in bEnd.3 cells.
The effect of melatonin was examined by western blot analysis, cell viability assays, measurement of intracellular reactive oxygen species (ROS), and immunocytochemistry (ICC).
Our results showed that treatment with melatonin prevents cell death and degradation of tight junction protein in the setting of OGD/R-induced injury.
In response to OGD/R injury of bEnd.3 cells, melatonin activates Akt, which promotes cell survival, and attenuates phosphorylation of JNK, which triggers apoptosis.
Thus, melatonin protects bEnd.3 cells against OGD/R-induced injury.
American Psychological Association (APA)
Song, Juhyun& Kang, So Mang& Lee, Won Taek& Park, Kyung Ah& Lee, Kyoung Min& Lee, Jong Eun. 2014. The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047072
Modern Language Association (MLA)
Song, Juhyun…[et al.]. The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047072
American Medical Association (AMA)
Song, Juhyun& Kang, So Mang& Lee, Won Taek& Park, Kyung Ah& Lee, Kyoung Min& Lee, Jong Eun. The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047072