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Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies
المؤلفون المشاركون
Nóbrega, Franklin Ferreira de Farias
Masson, Cintia J.
Mello, Carlos F.
Nascimento, Tiago S.
Leal-Cardoso, José H.
Salvadori, Mirian Stiebbe
de Almeida, Reinaldo Nóbrega
de Sousa, Damião Pergentino
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants.
We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats.
4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL.
For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM.
4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects.
Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results.
To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP).
The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the G A B A A receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site.
Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nóbrega, Franklin Ferreira de Farias& Salvadori, Mirian Stiebbe& Masson, Cintia J.& Mello, Carlos F.& Nascimento, Tiago S.& Leal-Cardoso, José H.…[et al.]. 2014. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047091
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nóbrega, Franklin Ferreira de Farias…[et al.]. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047091
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nóbrega, Franklin Ferreira de Farias& Salvadori, Mirian Stiebbe& Masson, Cintia J.& Mello, Carlos F.& Nascimento, Tiago S.& Leal-Cardoso, José H.…[et al.]. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047091
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047091
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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