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Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies
Joint Authors
Nóbrega, Franklin Ferreira de Farias
Masson, Cintia J.
Mello, Carlos F.
Nascimento, Tiago S.
Leal-Cardoso, José H.
Salvadori, Mirian Stiebbe
de Almeida, Reinaldo Nóbrega
de Sousa, Damião Pergentino
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants.
We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats.
4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL.
For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM.
4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects.
Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results.
To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP).
The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the G A B A A receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site.
Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.
American Psychological Association (APA)
Nóbrega, Franklin Ferreira de Farias& Salvadori, Mirian Stiebbe& Masson, Cintia J.& Mello, Carlos F.& Nascimento, Tiago S.& Leal-Cardoso, José H.…[et al.]. 2014. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047091
Modern Language Association (MLA)
Nóbrega, Franklin Ferreira de Farias…[et al.]. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047091
American Medical Association (AMA)
Nóbrega, Franklin Ferreira de Farias& Salvadori, Mirian Stiebbe& Masson, Cintia J.& Mello, Carlos F.& Nascimento, Tiago S.& Leal-Cardoso, José H.…[et al.]. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047091