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SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy
المؤلفون المشاركون
Ruan, Yang
Shen, Tao
Man, Yong
Li, Jian
Ding, Ling
Qin, Weiwei
Lin, Yajun
Xi, Chao
Lu, Yonggang
Dou, Lin
Zhu, Yuping
Cao, Yuan
Bian, Yunfei
Wang, Shu
Xiao, Chuanshi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Sirtuin 1 (SIRT1) is a member of the sirtuin family, which could activate cell survival machinery and has been shown to be protective in regulation of heart function.
Here, we determined the mechanism by which SIRT1 regulates Angiotensin II- (AngII-) induced cardiac hypertrophy and injury in vivo and in vitro.
Methods.
We analyzed SIRT1 expression in the hearts of control and AngII-induced mouse hypertrophy.
Female C57BL/6 mice were ovariectomized and pretreated with 17β-estradiol to measure SIRT1 expression.
Protein synthesis, cardiomyocyte surface area analysis, qRT-PCR, TUNEL staining, and Western blot were performed on AngII-induced mouse heart hypertrophy samples and cultured neonatal rat ventricular myocytes (NRVMs) to investigate the function of SIRT1.
Results.
SIRT1 expression was slightly upregulated in AngII-induced mouse heart hypertrophy in vivo and in vitro, accompanied by elevated cardiomyocyte apoptosis.
SIRT1 overexpression relieves AngII-induced cardiomyocyte hypertrophy and apoptosis.
17β-Estradiol was able to protect cardiomyocytes from AngII-induced injury with a profound upregulation of SIRT1 and activation of AMPK.
Moreover, estrogen receptor inhibitor ICI 182,780 and SIRT1 inhibitor niacinamide could block SIRT1’s protective effect.
Conclusions.
These results indicate that SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection during AngII-induced heart hypertrophy and injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shen, Tao& Ding, Ling& Ruan, Yang& Qin, Weiwei& Lin, Yajun& Xi, Chao…[et al.]. 2014. SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047094
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shen, Tao…[et al.]. SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047094
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shen, Tao& Ding, Ling& Ruan, Yang& Qin, Weiwei& Lin, Yajun& Xi, Chao…[et al.]. SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047094
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047094
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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