Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis
المؤلفون المشاركون
Mohamed, Mona M.
Sabet, Salwa
Peng, Dun-Fa
Nouh, M. Akram
El-Shinawi, Mohamed
El-Rifai, Wael
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Reactive oxygen species (ROS) play a crucial role in breast cancer initiation, promotion, and progression.
Inhibition of antioxidant enzymes that remove ROS was found to accelerate cancer growth.
Studies showed that inhibition of glutathione peroxidase-3 (GPX3) was associated with cancer progression.
Although the role of GPX3 has been studied in different cancer types, its role in breast cancer and its epigenetic regulation have not yet been investigated.
The aim of the present study was to investigate GPX3 expression and epigenetic regulation in carcinoma tissues of breast cancer patients’ in comparison to normal breast tissues.
Furthermore, we compared GPX3 level of expression and methylation status in aggressive phenotype inflammatory breast cancer (IBC) versus non-IBC invasive ductal carcinoma (IDC).
We found that GPX3 mRNA and protein expression levels were downregulated in the carcinoma tissues of IBC compared to non-IBC.
However, we did not detect significant correlation between GPX3 and patients’ clinical-pathological prosperities.
Promoter hypermethylation of GPX3 gene was detected in carcinoma tissues not normal breast tissues.
In addition, IBC carcinoma tissues showed a significant increase in the promoter hypermethylation of GPX3 gene compared to non-IBC.
Our results propose that downregulation of GPX3 in IBC may play a role in the disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamed, Mona M.& Sabet, Salwa& Peng, Dun-Fa& Nouh, M. Akram& El-Shinawi, Mohamed& El-Rifai, Wael. 2014. Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamed, Mona M.…[et al.]. Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamed, Mona M.& Sabet, Salwa& Peng, Dun-Fa& Nouh, M. Akram& El-Shinawi, Mohamed& El-Rifai, Wael. Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر