Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis
Joint Authors
Mohamed, Mona M.
Sabet, Salwa
Peng, Dun-Fa
Nouh, M. Akram
El-Shinawi, Mohamed
El-Rifai, Wael
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Reactive oxygen species (ROS) play a crucial role in breast cancer initiation, promotion, and progression.
Inhibition of antioxidant enzymes that remove ROS was found to accelerate cancer growth.
Studies showed that inhibition of glutathione peroxidase-3 (GPX3) was associated with cancer progression.
Although the role of GPX3 has been studied in different cancer types, its role in breast cancer and its epigenetic regulation have not yet been investigated.
The aim of the present study was to investigate GPX3 expression and epigenetic regulation in carcinoma tissues of breast cancer patients’ in comparison to normal breast tissues.
Furthermore, we compared GPX3 level of expression and methylation status in aggressive phenotype inflammatory breast cancer (IBC) versus non-IBC invasive ductal carcinoma (IDC).
We found that GPX3 mRNA and protein expression levels were downregulated in the carcinoma tissues of IBC compared to non-IBC.
However, we did not detect significant correlation between GPX3 and patients’ clinical-pathological prosperities.
Promoter hypermethylation of GPX3 gene was detected in carcinoma tissues not normal breast tissues.
In addition, IBC carcinoma tissues showed a significant increase in the promoter hypermethylation of GPX3 gene compared to non-IBC.
Our results propose that downregulation of GPX3 in IBC may play a role in the disease progression.
American Psychological Association (APA)
Mohamed, Mona M.& Sabet, Salwa& Peng, Dun-Fa& Nouh, M. Akram& El-Shinawi, Mohamed& El-Rifai, Wael. 2014. Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047131
Modern Language Association (MLA)
Mohamed, Mona M.…[et al.]. Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047131
American Medical Association (AMA)
Mohamed, Mona M.& Sabet, Salwa& Peng, Dun-Fa& Nouh, M. Akram& El-Shinawi, Mohamed& El-Rifai, Wael. Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047131