Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl4
المؤلفون المشاركون
al-Harbi, Mohamed M.
Sayed-Ahmed, Mohammed M.
Al-Rejaie, Salim S.
Alsurayea, Saad M.
Hafez, Mohamed M.
al-Harbi, Naif O.
al-Shabanah, Othman A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objectives.
The purpose of the study is to evaluate the hepatoprotective effect of rutin in carbon tetrachloride- (CCl4-) induced liver injuries in rat model.
Methods.
Forty male Wistar albino rats were divided into four groups.
Group I was the control group and received dimethyl sulphoxide (DMSO) and olive oil.
Group II received rutin.
Groups III was treated with CCl4.
Group IV was administered rutin after 48 h of CCl4 treatment.
Liver enzymes level, lipid profile, lipid peroxidation, and hydrogen peroxide were measured.
The genes expression levels were monitored by real time RT-PCR and western blot techniques.
Results.
CCl4 group showed significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), thiobarbituric acid reactive substances (TBAR), hydrogen peroxide (H2O2), and lipid profile and a significant decrease in glutathione peroxidase (GPx), glutathione S transferase (GST), catalase (CAT), paraoxonase-1 (PON-1), paraoxonase-3 (PON-3), peroxisome proliferator activated receptor delta (PPAR-δ), and ATP-binding cassette transporter 1 (ABAC1) genes expression levels.
Interestingly, rutin supplementation completely reversed the biochemical and gene expression levels induced by CCl4 to control values.
Conclusion.
CCl4 administration causes aberration of genes expression levels in oxidative stress pathway resulting in DNA damage and hepatotoxicity.
Rutin causes hepatoprotective effect through enhancing the antioxidant genes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hafez, Mohamed M.& al-Shabanah, Othman A.& al-Harbi, Naif O.& al-Harbi, Mohamed M.& Al-Rejaie, Salim S.& Alsurayea, Saad M.…[et al.]. 2014. Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl4. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047154
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hafez, Mohamed M.…[et al.]. Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl4. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1047154
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hafez, Mohamed M.& al-Shabanah, Othman A.& al-Harbi, Naif O.& al-Harbi, Mohamed M.& Al-Rejaie, Salim S.& Alsurayea, Saad M.…[et al.]. Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl4. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047154
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047154
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر